Author: da Cunha, Gilmara Franco; de Souza, Fernando Henrique Carlos; Levy-Neto, Maurício; Shinjo, Samuel Katsuyuki
Title: Chloroquine diphosphate: a risk factor for herpes zoster in patients with dermatomyositis/polymyositis Document date: 2013_5_23
ID: s9mqzqu4_10
Snippet: All of the patients were first started on corticosteroids (prednisone 1 mg/kg/day, administered orally), which were tapered gradually according to clinical and laboratory stability. In cases of high disease severity (dysphagia with risk of aspiration pneumonia, cutaneous vasculitis, or being refractory to oral corticosteroids), intravenous corticosteroids were administered (methyl prednisolone 1 g/day for three consecutive days). The following dr.....
Document: All of the patients were first started on corticosteroids (prednisone 1 mg/kg/day, administered orally), which were tapered gradually according to clinical and laboratory stability. In cases of high disease severity (dysphagia with risk of aspiration pneumonia, cutaneous vasculitis, or being refractory to oral corticosteroids), intravenous corticosteroids were administered (methyl prednisolone 1 g/day for three consecutive days). The following drugs were used alone or in combination for corticosteroid sparing: azathioprine (2-3 mg/kg/day), methotrexate (20-25 mg/week), cyclosporine (2-3 mg/kg/day), mycophenolate mofetil (2-3 g/day), leflunomide (20 mg/day), cyclophosphamide (0.5-1.0 g/m 2 of body surface), intravenous human immunoglobulin (1 g/ kg/day for two consecutive days) and chloroquine diphosphate (3-4 mg/kg/day).
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