Author: da Cunha, Gilmara Franco; de Souza, Fernando Henrique Carlos; Levy-Neto, Maurício; Shinjo, Samuel Katsuyuki
Title: Chloroquine diphosphate: a risk factor for herpes zoster in patients with dermatomyositis/polymyositis Document date: 2013_5_23
ID: s9mqzqu4_29
Snippet: Regarding the clinical evaluation, at least half of our patients had neurological sequelae. Six patients had simultaneous involvement of two dermatomes, while no cases of HZ recurrence were reported. Postherpetic neuralgia can result in severe pain such that patients are often unable to wear clothing that comes in contact with the lesions or be exposed to wind because of high skin sensitivity in regions such as the thorax and face. The incidence .....
Document: Regarding the clinical evaluation, at least half of our patients had neurological sequelae. Six patients had simultaneous involvement of two dermatomes, while no cases of HZ recurrence were reported. Postherpetic neuralgia can result in severe pain such that patients are often unable to wear clothing that comes in contact with the lesions or be exposed to wind because of high skin sensitivity in regions such as the thorax and face. The incidence of postherpetic neuralgia rises from 10% among individuals of all ages to as high as 40% among those aged 50 years and older (40) . A large prospective study identified four independent predictors of postherpetic neuralgia: older age, severe, acute pain, severe rash and a shorter duration of rash before consultation (41) . Although controversial, shortterm use of corticosteroids can reduce the pain severity and improve patient quality of life in the acute phase (42) . Note that high prednisone doses at the time of HZ diagnosis were found to decrease the incidence of postherpetic neuralgia in our patients.
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