Selected article for: "absence presence and viral rna"
Author: Longhini, Andrew P.; LeBlanc, Regan M.; Becette, Owen; Salguero, Carolina; Wunderlich, Christoph H.; Johnson, Bruce A.; D'Souza, Victoria M.; Kreutz, Christoph; Dayie, T. Kwaku
Title: Chemo-enzymatic synthesis of site-specific isotopically labeled nucleotides for use in NMR resonance assignment, dynamics and structural characterizations
  • Document date: 2016_4_7
    • ID: uhhtvdif_1
    Snippet: The tertiary architectures RNAs adopt are crucial for modulating gene expression across all domains of life, making them important targets of structural and dynamics studies. For instance, for riboswitches, the presence or absence of specific ligands drives the folding of one of two or more mutually exclusive, regulatory states (1) (2) (3) (4) . In viral RNA genomes, structured, untranslated regions commonly exercise direct control over viral gen.....
    Document: The tertiary architectures RNAs adopt are crucial for modulating gene expression across all domains of life, making them important targets of structural and dynamics studies. For instance, for riboswitches, the presence or absence of specific ligands drives the folding of one of two or more mutually exclusive, regulatory states (1) (2) (3) (4) . In viral RNA genomes, structured, untranslated regions commonly exercise direct control over viral gene expression (5, 6) . In the ribosome, the ability to distinguish between cognate and near-cognate tRNAs is governed in part by the extrahelical flipping of adenines A1492 and A1493 (7) . Both the global architecture and the subtle motions of specific base and ribose moieties are thus demonstrably important and can profoundly modulate an RNA's function (8) .

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