Author: da Cunha, Gilmara Franco; de Souza, Fernando Henrique Carlos; Levy-Neto, Maurício; Shinjo, Samuel Katsuyuki
Title: Chloroquine diphosphate: a risk factor for herpes zoster in patients with dermatomyositis/polymyositis Document date: 2013_5_23
ID: s9mqzqu4_2
Snippet: Viral infections, such as herpes zoster (HZ), have been increasingly reported in individuals with systemic autoimmune diseases. Among patients with systemic lupus erythematosus, for instance, there is an HZ prevalence of 4.5% (3) and an incidence of 6.4-58.7 events/1,000 patientyears (3, 4) . Corticosteroids (3) and immunosuppressive agents (4) (5) (6) , disease activity (5) (6) (7) (8) and the presence of anti-Sm autoantibodies (8) number among .....
Document: Viral infections, such as herpes zoster (HZ), have been increasingly reported in individuals with systemic autoimmune diseases. Among patients with systemic lupus erythematosus, for instance, there is an HZ prevalence of 4.5% (3) and an incidence of 6.4-58.7 events/1,000 patientyears (3, 4) . Corticosteroids (3) and immunosuppressive agents (4) (5) (6) , disease activity (5) (6) (7) (8) and the presence of anti-Sm autoantibodies (8) number among the possible risk factors for HZ in this population. The incidence of HZ in rheumatoid arthritis is 9.96 cases/1,000 patient-years (9) , and the risk factors in this cohort include older age (.45 years old), the presence of cancer, chronic lung disease, corticosteroid usage (10) , exposure to immunosuppressive (10) and immunobiological therapies (11) and immune system dysregulation (12) .
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