Selected article for: "dependent manner and protein expression"
Author: Dong, Xiaoxv; Fu, Jing; Yin, Xingbin; Yang, Chunjing; Zhang, Xin; Wang, Wenping; Du, Xueying; Wang, Qingling; Ni, Jian
Title: Cassiae semen: A review of its phytochemistry and pharmacology
  • Document date: 2017_6_29
    • ID: y5et8pqg_22
    Snippet: Neuroprotective activity. The ethanolic extract from the seeds of C. obtusifolia has been reported to have a neuroprotective effect in brain disease models. Kim et al (6) suggested that C. obtusifolia (25, 50 or 100 mg/kg) significantly attenuated scopolamine or transient bilateral common carotid artery occlusion (2VO)-induced memory impairment. These effects are mediated by the enhancement of the cholinergic nervous system via acetylcholinestera.....
    Document: Neuroprotective activity. The ethanolic extract from the seeds of C. obtusifolia has been reported to have a neuroprotective effect in brain disease models. Kim et al (6) suggested that C. obtusifolia (25, 50 or 100 mg/kg) significantly attenuated scopolamine or transient bilateral common carotid artery occlusion (2VO)-induced memory impairment. These effects are mediated by the enhancement of the cholinergic nervous system via acetylcholinesterase inhibition in a dose-dependent manner [half maximal inhibitory concentration (IC 50 )=81.6 µg/ml] (6). In addition, C. obtusifolia (10 or 50 mg/kg/day) exhibited a neuroprotective effect in a mouse transient global ischemia model due to its anti-inflammatory properties and the induced upregulated expression of phosphorylated cyclic AMP response element binding protein and brain-derived neurotrophic factor (78).

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