Author: Stäger, Simona; Rafati, Sima
Title: CD8(+) T Cells in Leishmania Infections: Friends or Foes? Document date: 2012_1_24
ID: uofygmeu_8
Snippet: This paradigm was later challenged when new findings arose from a more natural model of infection, where 100 metacyclic promastigotes were inoculated intradermally in the ears of C57BL/6 mice. In this model, Cd8 −/− and CD8 + T cell-depleted mice fail to control L. major infection, and CD8 + T cells were thought to be necessary for supporting Th1 responses (Belkaid et al., 2002) ......
Document: This paradigm was later challenged when new findings arose from a more natural model of infection, where 100 metacyclic promastigotes were inoculated intradermally in the ears of C57BL/6 mice. In this model, Cd8 −/− and CD8 + T cell-depleted mice fail to control L. major infection, and CD8 + T cells were thought to be necessary for supporting Th1 responses (Belkaid et al., 2002) .
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