Author: Kim, Eu Suk; Choe, Pyoeng Gyun; Park, Wan Beom; Oh, Hong Sang; Kim, Eun Jung; Nam, Eun Young; Na, Sun Hee; Kim, Moonsuk; Song, Kyoung-Ho; Bang, Ji Hwan; Park, Sang Won; Kim, Hong Bin; Kim, Nam Joong; Oh, Myoung-don
Title: Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection Document date: 2016_9_2
ID: vehb7dal_3
Snippet: In human infection with highly virulent respiratory viruses, such as avian influenza H5N1, H7N9, and Severe Acute Respiratory Syndrome (SARS) coronavirus, immunopathogenesis caused by hyper-induction of proinflammatory cytokines (also known as hypercytokinemia or cytokine storm) may play an important role in the disease progression and the ultimate mortality (7) (8) (9) . To better understand immunopathogenesis of MERS-CoV infection, we assessed .....
Document: In human infection with highly virulent respiratory viruses, such as avian influenza H5N1, H7N9, and Severe Acute Respiratory Syndrome (SARS) coronavirus, immunopathogenesis caused by hyper-induction of proinflammatory cytokines (also known as hypercytokinemia or cytokine storm) may play an important role in the disease progression and the ultimate mortality (7) (8) (9) . To better understand immunopathogenesis of MERS-CoV infection, we assessed host immune responses to and viral kinetics of MERS-CoV infection. We recently reported the viral shedding kinetics (10) and antibody response kinetics (11) . However, the innate immune response to MERS-CoV infection and the role of most cytokines in disease severity remains unclear.
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