Author: Paquin, Ashley; Onabajo, Olusegun O.; Tang, Wei; Prokunina-Olsson, Ludmila
Title: Comparative Functional Analysis of 12 Mammalian IFN-?4 Orthologs Document date: 2016_1_1
ID: sqxrwgif_31
Snippet: We used the human cell line, HepG2, because it has all necessary components for type-III IFN signaling and was used to characterize human IFN-l4. We recognize that a human cell line may not be optimal for all IFN-l4 orthologs because the human receptors (IFNLR1 and IL10R2) and other signaling components may not work efficiently with nonhuman IFN-l4s. However, our aim was to perform initial comparative characterization of IFN-l4 orthologs in the s.....
Document: We used the human cell line, HepG2, because it has all necessary components for type-III IFN signaling and was used to characterize human IFN-l4. We recognize that a human cell line may not be optimal for all IFN-l4 orthologs because the human receptors (IFNLR1 and IL10R2) and other signaling components may not work efficiently with nonhuman IFN-l4s. However, our aim was to perform initial comparative characterization of IFN-l4 orthologs in the same established experimental system. Additional studies on IFN-l4 orthologs should be performed in experimental systems relevant for species of interest.
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