Author: Paquin, Ashley; Onabajo, Olusegun O.; Tang, Wei; Prokunina-Olsson, Ludmila
Title: Comparative Functional Analysis of 12 Mammalian IFN-?4 Orthologs Document date: 2016_1_1
ID: sqxrwgif_34
Snippet: Confocal imaging showed that in most cases, IFN-l4 was expressed as a cytoplasmic protein, although, in some cases, it was also detected in the nucleus (such as in dog and panda, Supplementary Fig. S2 ). PSORT analysis (Nakai and Horton 1999) identified nuclear localization signals within IFN-l4, and some of the orthologs were predicted to be nuclear proteins (Supplementary Table S2 ); however, there was no correlation between these predictions a.....
Document: Confocal imaging showed that in most cases, IFN-l4 was expressed as a cytoplasmic protein, although, in some cases, it was also detected in the nucleus (such as in dog and panda, Supplementary Fig. S2 ). PSORT analysis (Nakai and Horton 1999) identified nuclear localization signals within IFN-l4, and some of the orthologs were predicted to be nuclear proteins (Supplementary Table S2 ); however, there was no correlation between these predictions and intracellular localization observed by confocal imaging. It is possible that nuclear localization of IFN-l4 might be an alternative option utilized in some specific conditions. Cytoplasmicnuclear shuttling has been reported for some factors involved in immune response ( Jans and Hassan 1998) , including IFN-g (Subramaniam and others 1999) and IRF3 (Kumar and others 2000) , and the possible functional effects associated with nuclear translocation of IFN-l4 should be further explored in relevant experimental models.
Search related documents:
Co phrase search for related documents- Confocal imaging and immune response: 1, 2
- Confocal imaging and intracellular localization: 1, 2
- Confocal imaging and nuclear localization: 1, 2
- Confocal imaging and nuclear localization signal: 1
- Confocal imaging and nuclear protein: 1, 2
- Confocal imaging and nuclear translocation: 1, 2, 3
- cytoplasmic protein and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- cytoplasmic protein and intracellular localization: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- cytoplasmic protein and nuclear localization: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- cytoplasmic protein and nuclear localization signal: 1, 2, 3
- cytoplasmic protein and nuclear protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- cytoplasmic protein and nuclear translocation: 1, 2, 3, 4
- experimental model and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- experimental model and nuclear protein: 1
- experimental model and relevant experimental model: 1, 2, 3, 4, 5, 6
- functional effect and immune response: 1, 2, 3
- functional effect and nuclear translocation: 1
- immune response and nuclear protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- immune response and nuclear translocation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
Co phrase search for related documents, hyperlinks ordered by date