Author: Al-Mulla, Hawaa M. N.; Turrell, Lauren; Smith, Nicola M.; Payne, Luke; Baliji, Surendranath; Züst, Roland; Thiel, Volker; Baker, Susan C.; Siddell, Stuart G.; Neuman, Benjamin W.
Title: Competitive Fitness in Coronaviruses Is Not Correlated with Size or Number of Double-Membrane Vesicles under Reduced-Temperature Growth Conditions Document date: 2014_4_1
ID: tfuupgkg_17
Snippet: Albts22 displayed the lowest relative DMV capacity among the viruses we examined (Fig. 4A) . The nearly tenfold reduction in Albts22 DMV capacity compared to wild-type corresponded well with nearly tenfold-lower production of infectious progeny (Table 1). However, DMV capacity correlated poorly with yield for Brts31, which produced infectious progeny at wild-type levels despite having only 35% of the DMV capacity of wild-type virus ( Table 3 ). T.....
Document: Albts22 displayed the lowest relative DMV capacity among the viruses we examined (Fig. 4A) . The nearly tenfold reduction in Albts22 DMV capacity compared to wild-type corresponded well with nearly tenfold-lower production of infectious progeny (Table 1). However, DMV capacity correlated poorly with yield for Brts31, which produced infectious progeny at wild-type levels despite having only 35% of the DMV capacity of wild-type virus ( Table 3 ). This suggested two possibilities: that Brts31 packages a reduced amount of RNA more efficiently than wild-type virus, or that Brts31 synthesizes normal amounts of RNA from a smallerthan-normal number of organelles.
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