Author: Ogimi, Chikara; Waghmare, Alpana; Kuypers, Jane; Xie, Hu; Leisenring, Wendy; Yeung, Cecilia; Seo, Sachiko; Choi, Su-Mi; Jerome, Keith; Englund, Janet; Boeckh, Michael
Title: Clinical Significance of Human Coronavirus in Bronchoalveolar Lavage Samples From Hematopoietic Cell Transplantation Recipients and Hematologic Malignancy Patients Document date: 2016_10_25
ID: swbw5q7b_3
Snippet: Results. We identified 37 cases with HCoV in BAL (Table). Among 23 samples available, 48% were OC43, 22% were NL63, 17% were 229E and 13% were HKU1. Overall, 23 cases (62%) required oxygen (O2) therapy at diagnosis and 19 cases (51%) died within 90 days from diagnosis. Twenty-one cases (57%) had other respiratory pathogen(s) detected, including viruses (N = 12), fungi (N = 10), and bacteria (N = 8). Mortality rates of these patients were similar .....
Document: Results. We identified 37 cases with HCoV in BAL (Table). Among 23 samples available, 48% were OC43, 22% were NL63, 17% were 229E and 13% were HKU1. Overall, 23 cases (62%) required oxygen (O2) therapy at diagnosis and 19 cases (51%) died within 90 days from diagnosis. Twenty-one cases (57%) had other respiratory pathogen(s) detected, including viruses (N = 12), fungi (N = 10), and bacteria (N = 8). Mortality rates of these patients were similar to those without co-pathogens (p-value 0.89). Multivariable Cox regression for mortality adjusted for cell source, co-pathogens, neutrophils, lymphocytes, monocytes, O2 use at diagnosis, steroid use and respiratory viruses (HCoV, RSV, Flu and PIV) was carried out. Adjusted hazard ratio of HCoV LRTD for overall mortality was 1.37 (95% CI 0.67-2.82, p-value 0.39) with RSV LRTD as a reference.
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