Author: Farhadi, Tayebeh; Hashemian, Seyed MohammadReza
Title: Computer-aided design of amino acid-based therapeutics: a review Document date: 2018_5_14
ID: q69f57el_47
Snippet: Peptide-driven pharmacophoric hypothesis is the most perceptive computational technique discovered in the peptidomimetics design. The method is especially useful when the X-ray structures of protein-protein complexes exist. 28 The main idea is to adapt the hot spot concept into the associated pharmacophoric feature concept. With a pharmacophorebased virtual screening process, this strategy can determine novel type 3 mimetics. 128 In fact, the sid.....
Document: Peptide-driven pharmacophoric hypothesis is the most perceptive computational technique discovered in the peptidomimetics design. The method is especially useful when the X-ray structures of protein-protein complexes exist. 28 The main idea is to adapt the hot spot concept into the associated pharmacophoric feature concept. With a pharmacophorebased virtual screening process, this strategy can determine novel type 3 mimetics. 128 In fact, the side chains of each amino acid can be simply categorized based on the conventional pharmacophoric characteristics, such as hydrogen bond donors and acceptors, aromatic ring and charged and hydrophobic centers.
Search related documents:
Co phrase search for related documents- acceptor hydrogen bond donor and hydrogen bond: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- acceptor hydrogen bond donor and hydrogen bond donor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- acceptor hydrogen bond donor and virtual screening: 1, 2, 3
- amino acid and aromatic ring: 1, 2, 3, 4
- amino acid and computational technique: 1, 2, 3
- amino acid and hot spot: 1, 2, 3, 4, 5, 6, 7, 8
- amino acid and hydrogen bond: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29
- amino acid and hydrogen bond donor: 1
- amino acid and hydrophobic charge: 1, 2, 3, 4, 5
- amino acid and peptide drive: 1
- amino acid and protein protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81
- amino acid and protein protein complex: 1, 2, 3, 4, 5, 6, 7
- amino acid and virtual screening: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34
- amino acid chain and protein protein: 1, 2
- aromatic ring and hydrogen bond: 1, 2, 3, 4, 5, 6, 7
- aromatic ring and hydrogen bond donor: 1
- aromatic ring and protein protein: 1, 2
- aromatic ring and virtual screening: 1, 2, 3
- computational technique and protein protein: 1
Co phrase search for related documents, hyperlinks ordered by date