Author: Al-Mulla, Hawaa M. N.; Turrell, Lauren; Smith, Nicola M.; Payne, Luke; Baliji, Surendranath; Züst, Roland; Thiel, Volker; Baker, Susan C.; Siddell, Stuart G.; Neuman, Benjamin W.
Title: Competitive Fitness in Coronaviruses Is Not Correlated with Size or Number of Double-Membrane Vesicles under Reduced-Temperature Growth Conditions Document date: 2014_4_1
ID: tfuupgkg_24
Snippet: DMVs are complex, containing viral replicase subunits, RNA, host membranes, and host proteins (4, 5, 7-13, 41, 42) , so some changes in DMV size and number may be related to the efficiency of the many poorly understood processes that contribute to DMV formation. The results presented here should be taken with two caveats: that the effects of the mutations may be indirect, and that comparisons of growth and competition could be performed only at r.....
Document: DMVs are complex, containing viral replicase subunits, RNA, host membranes, and host proteins (4, 5, 7-13, 41, 42) , so some changes in DMV size and number may be related to the efficiency of the many poorly understood processes that contribute to DMV formation. The results presented here should be taken with two caveats: that the effects of the mutations may be indirect, and that comparisons of growth and competition could be performed only at reduced temperature. Although all ts viruses except for Albts22 matched the output of the wild type at reduced temperature, reduced temperature may affect replication and the processes that lead to DMV formation differently.
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