Author: Paquin, Ashley; Onabajo, Olusegun O.; Tang, Wei; Prokunina-Olsson, Ludmila
Title: Comparative Functional Analysis of 12 Mammalian IFN-?4 Orthologs Document date: 2016_1_1
ID: sqxrwgif_7
Snippet: Although the function of human IFN-l4 is not completely understood, its ability to induce IFN signaling and antiviral response against several pathogens has been clearly demonstrated. It is possible that the human and animal IFN-l4 proteins have similar functions, which are relevant to antiviral response. In this study, we provide initial functional characterization of IFN-l4 orthologs from 12 mammalian species, including those commonly used in b.....
Document: Although the function of human IFN-l4 is not completely understood, its ability to induce IFN signaling and antiviral response against several pathogens has been clearly demonstrated. It is possible that the human and animal IFN-l4 proteins have similar functions, which are relevant to antiviral response. In this study, we provide initial functional characterization of IFN-l4 orthologs from 12 mammalian species, including those commonly used in biomedical research. Studies of IFN-l4 across species should help improve our understanding of the biology of this clinically important IFN in normal and disease conditions.
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