Author: Al-Mulla, Hawaa M. N.; Turrell, Lauren; Smith, Nicola M.; Payne, Luke; Baliji, Surendranath; Züst, Roland; Thiel, Volker; Baker, Susan C.; Siddell, Stuart G.; Neuman, Benjamin W.
Title: Competitive Fitness in Coronaviruses Is Not Correlated with Size or Number of Double-Membrane Vesicles under Reduced-Temperature Growth Conditions Document date: 2014_4_1
ID: tfuupgkg_5
Snippet: Wild-type MHV-inf-1 and five mutant MHV strains selected on the basis of defective RNA synthesis at 40°C were used in this study (Fig. 1 ). Brts31 contains a mutation in a region that likely forms an interdomain flexible linker in nsp3 (29, 30) , which paradoxically interferes with the function of the nsp5 main proteinase (M pro ) at 40°C (14) ......
Document: Wild-type MHV-inf-1 and five mutant MHV strains selected on the basis of defective RNA synthesis at 40°C were used in this study (Fig. 1 ). Brts31 contains a mutation in a region that likely forms an interdomain flexible linker in nsp3 (29, 30) , which paradoxically interferes with the function of the nsp5 main proteinase (M pro ) at 40°C (14) .
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