Cytokines Interleukin 4 (IL-4) and Interleukin 10 (IL-10) Gene Polymorphisms as Potential Host Susceptibility Factors in Virus-Induced Encephalitis

Yu, Ying; Chen, Ying; Wang, Feng-Ling; Sun, Jing; Li, Hai-Jun; Liu, Jia-Ming

We found that T allele, and GT, TT, and GT + TT genotypes in IL-10 rs1800872 were risk factors for virus-induced encephalitis. Attempts to control the subsequent inflammation and decreased tissue destruction were of particular importance to CNS infections, including virus-induced encephalitis, as well as the regulation IL-10 expressions, could possibly diminish the tissue damage in acute encephalitis [37] . IL-10 rs1800872 polymorphism might be a risk factor for colorectal cancer development in European populations and the A/C allele of IL-10 rs1800872 might raise the risk for RA [46, 47] . Previous studies have revealed that polymorphisms in IL-10-592C/A (rs1800872) were associated with risk of acute myeloid leukemia and enhanced the likelihood of early-onset preeclampsia [48, 49] . IL10-592C/A polymorphisms were correlated with risk factors of coronary heart disease (CHD). Additionally, the A allele may be a risk factor for CHD [50] . Polymorphisms of IL-10 rs1800872 were recorded in order to draw links and data-related correlations with the increased production of IL-10 protein in peritoneal fluid (PF) in endometriosis patients [51] . Furthermore, haplotypes of IL10-rs1800872 had significant correlation with the increase of risk for early pregnancy loss [52] .