Author: Zhang, XiZhen; Wang, XiaoDan; Zhao, DongHai; Meng, XiangYu; Zhao, XingHong; Yu, XiangHui; Kong, Wei
Title: Design and immunogenicity assessment of HIV-1 virus-like particles as a candidate vaccine Document date: 2011_12_16
ID: xxypq3wd_3
Snippet: VLPs are now considered one of the most attractive candidate vaccines for HIV and multiple VLP-based vaccines for HIV-1 are currently under investigation [12, [17] [18] [19] [20] [21] [22] . However, it is still generally desirable to enhance VLP immunogenicity. In this study, we report the construction of VLPs by cotransfecting two kinds of plasmids into HEK293 cells to obtain a mammalian cell line that efficiently and stably expresses the HIV-1.....
Document: VLPs are now considered one of the most attractive candidate vaccines for HIV and multiple VLP-based vaccines for HIV-1 are currently under investigation [12, [17] [18] [19] [20] [21] [22] . However, it is still generally desirable to enhance VLP immunogenicity. In this study, we report the construction of VLPs by cotransfecting two kinds of plasmids into HEK293 cells to obtain a mammalian cell line that efficiently and stably expresses the HIV-1 structural proteins Gag, pol, and Env. The VLPs induce specific humoral and cellular immune responses after immunization, without any adjuvant.
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