Author: Zhang, XiZhen; Wang, XiaoDan; Zhao, DongHai; Meng, XiangYu; Zhao, XingHong; Yu, XiangHui; Kong, Wei
Title: Design and immunogenicity assessment of HIV-1 virus-like particles as a candidate vaccine Document date: 2011_12_16
ID: xxypq3wd_37
Snippet: During natural infection, HIV-specific Th1 cells, CTLs, and associated antiviral cytokines (IFN-ï§, TNF-ï¡, IL-2) play key roles in virus recognition [24] . HIV-1-specific CD8 + T cells were measured in vitro by determining splenic IFN-ï§ production in response to brief re-stimulation with CTL epitopes, as measured by ELISPOT. The results indicate that the IFN-ï§ response to VLPs immunization at 25 ïg was the same as that for 12.5 and 0.5 ï.....
Document: During natural infection, HIV-specific Th1 cells, CTLs, and associated antiviral cytokines (IFN-ï§, TNF-ï¡, IL-2) play key roles in virus recognition [24] . HIV-1-specific CD8 + T cells were measured in vitro by determining splenic IFN-ï§ production in response to brief re-stimulation with CTL epitopes, as measured by ELISPOT. The results indicate that the IFN-ï§ response to VLPs immunization at 25 ïg was the same as that for 12.5 and 0.5 ïg, and 2.5 ïg was also lower than 12.5 ïg, indicating that 12.5 ïg was needed to induce a cellular immune response in mouse (Figure 7 ).
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