Author: Gadsby, Naomi J.; Russell, Clark D.; McHugh, Martin P.; Mark, Harriet; Conway Morris, Andrew; Laurenson, Ian F.; Hill, Adam T.; Templeton, Kate E.
Title: Comprehensive Molecular Testing for Respiratory Pathogens in Community-Acquired Pneumonia Document date: 2016_4_1
ID: s04e6po9_1
Snippet: Community-acquired pneumonia (CAP) is a common infectious disease with an estimated incidence of 2-11 cases per 1000 adults in the developed world and a mortality rate of 2%-14% [1] [2] [3] [4] [5] . Due to the range of pathogens responsible for CAP, in moderate or severe infection, broad-spectrum antimicrobial cover should be initiated before de-escalating to narrowspectrum pathogen-directed agents once a microbiological diagnosis has been made .....
Document: Community-acquired pneumonia (CAP) is a common infectious disease with an estimated incidence of 2-11 cases per 1000 adults in the developed world and a mortality rate of 2%-14% [1] [2] [3] [4] [5] . Due to the range of pathogens responsible for CAP, in moderate or severe infection, broad-spectrum antimicrobial cover should be initiated before de-escalating to narrowspectrum pathogen-directed agents once a microbiological diagnosis has been made [1, 5] . Unfortunately, de-escalation is uncommon in practice because current diagnostic methods may identify a pathogen in only 30%-40% of patients with CAP [4, 6, 7] . Recent studies have highlighted the need for more timely and sensitive microbiological diagnostic methods in CAP, particularly for bacteria and in the common scenario of antibiotic administration prior to sampling [4, 8, 9] .
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