Author: Alexander Rosenberg; Iuliana V. Ene; Maayan Bibi; Shiri Zakin; Ella Shtifman Segal; Naomi Ziv; Alon M. Dahan; Arnaldo L. Colombo; Richard J. Bennett; Judith Berman
Title: Clearing the FoG: Antifungal tolerance is a subpopulation effect that is distinct from resistance and is associated with persistent candidemia Document date: 2017_10_20
ID: begn4tsd_6
Snippet: fluoxetine, a serotonin inhibitor 21 ; and fluphenazine, an antipsychotic drug that stimulates ABC transporter expression and indirectly inhibits calcineurin via calmodulin 23,28,95 . FLC + adjuvant 233 cleared tolerance for all 7 clinical isolates tested (Fig. 4a,b) , as well as for a longitudinal series 234 from a single HIV patient 96,97 that had acquired resistance over time, and for a set of persistent 235 and non-persistent clinical isolate.....
Document: fluoxetine, a serotonin inhibitor 21 ; and fluphenazine, an antipsychotic drug that stimulates ABC transporter expression and indirectly inhibits calcineurin via calmodulin 23,28,95 . FLC + adjuvant 233 cleared tolerance for all 7 clinical isolates tested (Fig. 4a,b) , as well as for a longitudinal series 234 from a single HIV patient 96,97 that had acquired resistance over time, and for a set of persistent 235 and non-persistent clinical isolates ( Supplementary Fig. 7a-d) . Importantly, most adjuvants had 236 little or no effect on RAD/MIC levels (Fig. 4a,b and Supplementary Fig. 7a-
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