Author: Lemaire, D.; Barbosa, T.; Rihet, P.
Title: Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology Document date: 2011_10_28
ID: q2y7fewk_2
Snippet: New high-throughput technologies, new statistical and bioinformatics tools, and new biological concepts such as molecular networks should help in overcoming some of these difficulties. In particular, the availability of complete microbe genome sequences, including the sequences of multiple strains of a pathogen, may help in identifying new candidate antigens (2) . Furthermore, new high-throughput technologies may lead to a better understanding of.....
Document: New high-throughput technologies, new statistical and bioinformatics tools, and new biological concepts such as molecular networks should help in overcoming some of these difficulties. In particular, the availability of complete microbe genome sequences, including the sequences of multiple strains of a pathogen, may help in identifying new candidate antigens (2) . Furthermore, new high-throughput technologies may lead to a better understanding of genetic variation in resistance to infectious disease and in response to vaccination. Here, we will present recent advances in genomic-based vaccine approaches, genetic control in www.bjournal.com.br Braz J Med Biol Res 45 (5) 2012 infectious diseases, and we will discuss the possibility of vaccines for target groups or personalized vaccines.
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