Selected article for: "Nucleic acid and probe hybridization"
Author: Jabado, Omar J.; Liu, Yang; Conlan, Sean; Quan, P. Lan; Hegyi, Hédi; Lussier, Yves; Briese, Thomas; Palacios, Gustavo; Lipkin, W. I.
Title: Comprehensive viral oligonucleotide probe design using conserved protein regions
  • Document date: 2007_12_13
    • ID: xfzhn1n1_30
    Snippet: Probe sequence composition is a major determinant of hybridization signal and is responsible for much of the variance between probes that target the same nucleic acid strand. Probe-target thermodynamics have been successfully modeled to predict fluorescence (41, 42) , control for variance (43) and even estimate concentrations of target detected in samples (44) . Observing that some probes with more than five mismatches to their targets showed str.....
    Document: Probe sequence composition is a major determinant of hybridization signal and is responsible for much of the variance between probes that target the same nucleic acid strand. Probe-target thermodynamics have been successfully modeled to predict fluorescence (41, 42) , control for variance (43) and even estimate concentrations of target detected in samples (44) . Observing that some probes with more than five mismatches to their targets showed strong fluorescent signal, we concluded that sequence composition is a major factor in our array platform.

    Search related documents:
    Co phrase search for related documents
    • array platform and hybridization signal: 1, 2
    • array platform and Probe sequence: 1
    • array platform and probe target: 1
    • fluorescent signal and hybridization signal: 1
    • fluorescent signal and nucleic acid strand: 1
    • fluorescent signal and Probe sequence: 1, 2, 3
    • fluorescent signal and probe target: 1, 2, 3, 4, 5
    • fluorescent signal and strong fluorescent signal: 1, 2
    • fluorescent signal and target concentration: 1, 2
    • hybridization signal and Probe sequence: 1, 2, 3, 4, 5, 6
    • hybridization signal and probe target: 1, 2, 3, 4, 5, 6, 7
    • hybridization signal and sequence composition: 1
    • hybridization signal and target concentration: 1
    • major factor and sequence composition: 1, 2
    • mismatch probe and Probe sequence: 1, 2, 3, 4, 5, 6
    • mismatch probe and probe target: 1, 2, 3, 4
    • mismatch probe and target mismatch probe: 1, 2, 3
    • Probe sequence and target mismatch probe: 1, 2
    • probe target and sequence composition: 1