Title: Constitutive and basal secretion from the endocrine cell line, AtT-20 Document date: 1991_3_1
ID: tqgsavnr_30_1
Snippet: ected cells, 75 % of the labeled r light chain was secreted during the first chase interval and the half time of secretion was '~1 h. Stimulation with 8-Br-cAMP did not enhance the amount of light chain secreted (Fig. 4 D) . Since transfected trypsinogen was secreted from the AtT-20 variant at a rate indistinguishable from that of the constitutively secreted r-light chain in transfected wild type cells (Fig. 4, B and D) , it is very likely that u.....
Document: ected cells, 75 % of the labeled r light chain was secreted during the first chase interval and the half time of secretion was '~1 h. Stimulation with 8-Br-cAMP did not enhance the amount of light chain secreted (Fig. 4 D) . Since transfected trypsinogen was secreted from the AtT-20 variant at a rate indistinguishable from that of the constitutively secreted r-light chain in transfected wild type cells (Fig. 4, B and D) , it is very likely that unstimulated secretion in the variant is from the constitutive secretory pathway.
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