Author: Benharouga, Mohamed; Haardt, Martin; Kartner, Norbert; Lukacs, Gergely L.
Title: Cooh-Terminal Truncations Promote Proteasome-Dependent Degradation of Mature Cystic Fibrosis Transmembrane Conductance Regulator from Post-Golgi Compartments Document date: 2001_5_28
ID: q3agdeju_29
Snippet: In light of efficient clathrin-dependent internalization of CFTR (Prince et al., 1994 (Prince et al., , 1999 Lukacs et al., 1997; Bradbury, 1999 ) and proteolysis of other plasma membrane-resident ATP-binding cassette transporters in the vacuolar/lysosomal compartments (Loayza and Michaelis, 1998; Hicke, The Journal of Cell Biology, Volume 153, 2001 960 1999; Katzmann et al., 1999) , we hypothesized that COOHterminal truncations may interfere wit.....
Document: In light of efficient clathrin-dependent internalization of CFTR (Prince et al., 1994 (Prince et al., , 1999 Lukacs et al., 1997; Bradbury, 1999 ) and proteolysis of other plasma membrane-resident ATP-binding cassette transporters in the vacuolar/lysosomal compartments (Loayza and Michaelis, 1998; Hicke, The Journal of Cell Biology, Volume 153, 2001 960 1999; Katzmann et al., 1999) , we hypothesized that COOHterminal truncations may interfere with the recycling of CFTR and lead to premature endolysosomal proteolysis.
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