Author: Paquin, Ashley; Onabajo, Olusegun O.; Tang, Wei; Prokunina-Olsson, Ludmila
Title: Comparative Functional Analysis of 12 Mammalian IFN-?4 Orthologs Document date: 2016_1_1
ID: sqxrwgif_30
Snippet: Once the protein sequence of human IFN-l4 was known, it was used to search for IFN-l4 orthologs in all *100 vertebrate species with genomic information available through the UCSC Genome browser. Complete ORFs encoding IFN-l4 proteins were found in several mammalian species, but not in nonmammals (Key and others 2014) . The regions corresponding to IFN-l4 could not be found in the mouse and rat genomes, although orthologs for IFN-l2 and IFN-l3 are.....
Document: Once the protein sequence of human IFN-l4 was known, it was used to search for IFN-l4 orthologs in all *100 vertebrate species with genomic information available through the UCSC Genome browser. Complete ORFs encoding IFN-l4 proteins were found in several mammalian species, but not in nonmammals (Key and others 2014) . The regions corresponding to IFN-l4 could not be found in the mouse and rat genomes, although orthologs for IFN-l2 and IFN-l3 are present in these species. Now, we generated expression constructs for 11 IFN-l4 orthologs ( Fig. 1 and Supplementary Table S1) and tested their functionality in a human hepatoma cell line, HepG2, in comparison with human IFN-l4.
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