Author: Liu, Xingjian; Yang, Xin; Mehboob, Arslan; Hu, Xiaoyuan; Yi, Yongzhu; Li, Yinü; Zhang, Zhifang
Title: A construction strategy for a baculovirus-silkworm multigene expression system and its application for coexpression of type I and type II interferons Document date: 2019_12_19
ID: uxzeg16r_4
Snippet: Chicken IFN-α (chIFN-α) is a type I IFN. Research has revealed its antiviral potential against Rous sarcoma virus, Newcastle disease virus, infectious bursal disease virus, and avian influenza virus in vitro and in vivo (Jiang, Yang, & Kapczynski, 2011; Marcus, van der Heide, & Sekellick, 1999; Meng et al., 2011; O'Neill, Livant, & Ewald, 2010) . Chicken IFN-γ (chIFN-γ) is a type II IFN. It demonstrates avian virus inhibition both in vitro an.....
Document: Chicken IFN-α (chIFN-α) is a type I IFN. Research has revealed its antiviral potential against Rous sarcoma virus, Newcastle disease virus, infectious bursal disease virus, and avian influenza virus in vitro and in vivo (Jiang, Yang, & Kapczynski, 2011; Marcus, van der Heide, & Sekellick, 1999; Meng et al., 2011; O'Neill, Livant, & Ewald, 2010) . Chicken IFN-γ (chIFN-γ) is a type II IFN. It demonstrates avian virus inhibition both in vitro and in vivo and has the capability to prevent poultry coccidiosis (Cardenas-Garcia et al., 2016; Khatri & Sharma, 2008; Shah et al., 2010) . Studies also illustrate that chIFN-γ enhances the growth performance of reared broilers (Lowenthal, 2001) . These two IFNs have an immune synergism effect. The combination of chIFN-α and chIFN-γ can significantly enhance viral inhibition and elicit an antiviral state (Plachy et al., 1999; Sekellick et al., 1998 ).
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