Author: Benharouga, Mohamed; Haardt, Martin; Kartner, Norbert; Lukacs, Gergely L.
Title: Cooh-Terminal Truncations Promote Proteasome-Dependent Degradation of Mature Cystic Fibrosis Transmembrane Conductance Regulator from Post-Golgi Compartments Document date: 2001_5_28
ID: q3agdeju_45
Snippet: Nonnative or partially denatured soluble proteins are subjected to ubiquitination and/or proteasome-mediated degradation (Pacifici et al., 1993; Sadis et al., 1995; Michalek et al., 1996; Gilon et al., 1998; Laney and Hochstrasser, 1999) . A similar scenario may prevail for T70 CFTR if the COOH-terminal tail is engaged in the structural stabilization of CFTR in the post-ER compartment. A large body of evidence demonstrates the existence of intra-.....
Document: Nonnative or partially denatured soluble proteins are subjected to ubiquitination and/or proteasome-mediated degradation (Pacifici et al., 1993; Sadis et al., 1995; Michalek et al., 1996; Gilon et al., 1998; Laney and Hochstrasser, 1999) . A similar scenario may prevail for T70 CFTR if the COOH-terminal tail is engaged in the structural stabilization of CFTR in the post-ER compartment. A large body of evidence demonstrates the existence of intra-and intermolecular interactions in CFTR (Seibert et al., 1996; Ostedgaard et al., 1997 Ostedgaard et al., , 2000 Hall et al., 1998; Neville et al., 1998; Zhang et al., 1998; Naren et al., 1999; Lu and Pedersen, 2000) .
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