Author: Lemaire, D.; Barbosa, T.; Rihet, P.
Title: Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology Document date: 2011_10_28
ID: q2y7fewk_15
Snippet: In general, the methodologies used for identification and analysis of vaccine candidate antigens are based on the assumption that surface and secreted proteins will induce a protective humoral immune response. That is true for almost all extracellular pathogens, but the presence of antibodies is not always associated with protection against intracellular pathogens. Then, eliciting both antibody and T-cell immune responses can be an important prop.....
Document: In general, the methodologies used for identification and analysis of vaccine candidate antigens are based on the assumption that surface and secreted proteins will induce a protective humoral immune response. That is true for almost all extracellular pathogens, but the presence of antibodies is not always associated with protection against intracellular pathogens. Then, eliciting both antibody and T-cell immune responses can be an important property of the candidate antigens to be evaluated.
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