Author: Gadsby, Naomi J.; Russell, Clark D.; McHugh, Martin P.; Mark, Harriet; Conway Morris, Andrew; Laurenson, Ian F.; Hill, Adam T.; Templeton, Kate E.
Title: Comprehensive Molecular Testing for Respiratory Pathogens in Community-Acquired Pneumonia Document date: 2016_4_1
ID: s04e6po9_32
Snippet: We found a higher mean bacterial load by PCR in culturepositive specimens in comparison to culture-negative specimens. However, the culture-negative group was more frequently antibiotic exposed, and antibiotic exposure was also associated with lower bacterial loads. As PCR is able to detect dead as well as viable bacteria, it is not clear for how long bacterial loads might be detectable after initiation of appropriate antibiotics in patients with.....
Document: We found a higher mean bacterial load by PCR in culturepositive specimens in comparison to culture-negative specimens. However, the culture-negative group was more frequently antibiotic exposed, and antibiotic exposure was also associated with lower bacterial loads. As PCR is able to detect dead as well as viable bacteria, it is not clear for how long bacterial loads might be detectable after initiation of appropriate antibiotics in patients with CAP and if monitoring of bacterial load by PCR would be useful in these patients. With the quantitative molecular tools now available for the relevant bacteria, these issues can also be further investigated.
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