Author: Farhadi, Tayebeh; Hashemian, Seyed MohammadReza
Title: Computer-aided design of amino acid-based therapeutics: a review Document date: 2018_5_14
ID: q69f57el_5
Snippet: Computer-aided design of amino acid-based therapeutics Figure 2A ) and Leuprolide (PDB ID: 1YY2; Figure 2B ) were obtained from the Protein Data Bank (PDB; http://www. rcsb.org/) and visualized by PyMol tool. The structure of Spaglumic acid was retrieved (in MOL format) from Pub-Chem database (https://pubchem.ncbi.nlm.nih.gov/) with the PubChem ID 188803 ( Figure 2C ) and visualized using PyMol. Aldesleukin, a lymphokine, is a recombinant protein.....
Document: Computer-aided design of amino acid-based therapeutics Figure 2A ) and Leuprolide (PDB ID: 1YY2; Figure 2B ) were obtained from the Protein Data Bank (PDB; http://www. rcsb.org/) and visualized by PyMol tool. The structure of Spaglumic acid was retrieved (in MOL format) from Pub-Chem database (https://pubchem.ncbi.nlm.nih.gov/) with the PubChem ID 188803 ( Figure 2C ) and visualized using PyMol. Aldesleukin, a lymphokine, is a recombinant protein used to treat adults with metastatic renal cell carcinoma (https://www.drugbank.ca/drugs/DB00041). Leuprolide, a synthetic nine-residue peptide analog of gonadotropin releasing hormone, is used to treat advanced prostate cancer (https://www.drugbank.ca/drugs/DB00007). Spaglumic acid is used in allergic conditions such as allergic conjunctivitis. The drug belongs to a class of peptidomimetics known as hybrid peptides. Hybrid peptides contain at least two dissimilar types of amino acids (alpha, beta, gamma or delta) linked to each other via a peptide bond (https://www.drugbank.ca/ drugs/DB08835).
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