Corticosteroid-induced Osteonecrosis of the Femoral Head: Detection, Diagnosis, and Treatment in Earlier Stages

Liu, Li-Hua; Zhang, Qing-Yu; Sun, Wei; Li, Zi-Rong; Gao, Fu-Qiang

Patients with SLE have positive correlations with ONFH as an independent risk factor. [30] Shigemura et al. [7] conducted a prospective study and showed a higher incidence of corticosteroid-induced ONFH in the SLE group than the non-SLE group. Further, SLE recurrence was a risk factor for new osteonecrosis development, [31, 32] and magnetic resonance imaging (MRI) for osteonecrosis screening should be recommended if SLE recurs. Another study showed that a high triglyceride level was an important risk factor for silent ONFH in patients with SLE. [20] Apostolopoulos and Morand [33] showed evidence for the harmful effects of glucocorticoids in SLE and proposed therapeutic options that would reduce reliance on glucocorticoids.