Selected article for: "SARS CoV spike protein and spike protein"
Author: Samuel J. S. Rubin; Samuel Robert Falkson; Nicholas Degner; Catherine Blish
Title: Clinical characteristics associated with COVID-19 severity in California
  • Document date: 2020_3_30
    • ID: as6tbfrh_14
    Snippet: The potential role of the RAAS system in COVID-19 pathogenesis stems from mounting sequence and structural evidence indicating entry of SARS-CoV-2 via interaction of its spike protein with its human host receptor angiotensin-converting enzyme 2 (ACE2) (5). It is difficult to predict the effects of RAAS blockade in treatment of COVID-19, as it may increase expression of ACE2, with known anti-inflammatory and pulmonary protective properties, yet si.....
    Document: The potential role of the RAAS system in COVID-19 pathogenesis stems from mounting sequence and structural evidence indicating entry of SARS-CoV-2 via interaction of its spike protein with its human host receptor angiotensin-converting enzyme 2 (ACE2) (5). It is difficult to predict the effects of RAAS blockade in treatment of COVID-19, as it may increase expression of ACE2, with known anti-inflammatory and pulmonary protective properties, yet simultaneously promote viral entry (6). However, RAAS blockade may also increase soluble ACE2, which could serve as a decoy receptor protecting against viral entry.

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