Selected article for: "association study and Genome wide association study"
Author: Lemaire, D.; Barbosa, T.; Rihet, P.
Title: Coping with genetic diversity: the contribution of pathogen and human genomics to modern vaccinology
  • Document date: 2011_10_28
    • ID: q2y7fewk_22
    Snippet: The first genome-wide association study in infectious disease was published by Fellay et al. (40) , who found an association of HLA-B and HLA-C with HIV virus load, and of RNF39 and ZNRD1 with disease progression. More recently, several genome-wide association studies have been published for malaria, hepatitis B, and hepatitis C. The best signals of association were found at the HBB locus for severe malaria (35) , at the HLA-DP locus for hepatiti.....
    Document: The first genome-wide association study in infectious disease was published by Fellay et al. (40) , who found an association of HLA-B and HLA-C with HIV virus load, and of RNF39 and ZNRD1 with disease progression. More recently, several genome-wide association studies have been published for malaria, hepatitis B, and hepatitis C. The best signals of association were found at the HBB locus for severe malaria (35) , at the HLA-DP locus for hepatitis B (41) , and at the IL28B locus for hepatitis C (42, 43) . All the studies were based on single nucleotide polymorphism (SNP) arrays: 500,000 SNPs were genotyped in the HIV, malaria, and hepatitis B studies, while 900,000 SNPs were analyzed in the hepatitis C study.

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