Selected article for: "cell entry and entry step"

Author: Maroun, Justin; Muñoz-Alía, Miguel; Ammayappan, Arun; Schulze, Autumn; Peng, Kah-Whye; Russell, Stephen
Title: Designing and building oncolytic viruses
  • Document date: 2017_3_31
  • ID: qr1gsmqw_37
    Snippet: Beyond the step of cell entry, viruses are exquisite sensors of intracellular processes and can therefore be adapted or engineered in several ways for intracellular targeting of cancer cells. This is best understood by considering some fundamental aspects of the interplay between a virus and an infected cell. The incoming virus aims to usurp the cellular synthetic machinery for generation of progeny viruses. The cell resists this takeover bid by .....
    Document: Beyond the step of cell entry, viruses are exquisite sensors of intracellular processes and can therefore be adapted or engineered in several ways for intracellular targeting of cancer cells. This is best understood by considering some fundamental aspects of the interplay between a virus and an infected cell. The incoming virus aims to usurp the cellular synthetic machinery for generation of progeny viruses. The cell resists this takeover bid by rapidly detecting virus invasion, then triggering a signaling cascade that leads to establishment of an antiviral state and release of interferon which induces an anti viral state in adjacent cells [105, 106] . The antiviral state is very complex but suppression of protein translation is a key component. Apoptosis is also triggered by the virus detection machinery so that the infected cell dies before it is able to manufacture virus progeny [107] .

    Search related documents:
    Co phrase search for related documents
    • antiviral state and virus detection: 1, 2
    • antiviral state and virus progeny: 1
    • cancer cell and virus progeny: 1, 2
    • cell entry and virus invasion: 1, 2, 3, 4, 5, 6
    • cell entry and virus progeny: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • infected cell and virus invasion: 1, 2
    • infected cell and virus progeny: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
    • infected cell virus and virus invasion: 1, 2
    • infected cell virus and virus progeny: 1, 2, 3
    • key component and virus invasion: 1
    • key component and virus progeny: 1
    • progeny virus and virus progeny: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • progeny virus generation and virus progeny: 1, 2, 3, 4
    • protein translation and virus progeny: 1, 2, 3
    • protein translation suppression and virus progeny: 1
    • viral state and virus invasion: 1
    • viral state and virus progeny: 1