Selected article for: "cell surface and LE cat"
Author: Hasegawa, Daisuke; Ohnishi, Yumi; Koyama, Eiji; Matsunaga, Satoru; Ohtani, Shouhei; Nakanishi, Akio; Shiga, Takanori; Chambers, James K.; Uchida, Kazuyuki; Yokoi, Norihiko; Fukata, Yuko; Fukata, Masaki
Title: Deleted in colorectal cancer (netrin-1 receptor) antibodies and limbic encephalitis in a cat with hippocampal necrosis
  • Document date: 2019_4_3
    • ID: zin6j6dc_2
    Snippet: A cerebrospinal fluid tap was not performed due to suspected increased intracranial pressure indicated by narrowing sulci, ventricles (on transverse and dorsal planes), and cisterna magna (on sagittal plane) (not shown). From these MRI findings, feline hippocampal necrosis (FHN) and limbic encephalitis (LE) were suspected. [1] [2] [3] [4] [5] [6] [7] After MRI, in addition to ZNS (serum level was 15.3 μg/mL), prednisolone (1 mg/kg, PO q24h for 4.....
    Document: A cerebrospinal fluid tap was not performed due to suspected increased intracranial pressure indicated by narrowing sulci, ventricles (on transverse and dorsal planes), and cisterna magna (on sagittal plane) (not shown). From these MRI findings, feline hippocampal necrosis (FHN) and limbic encephalitis (LE) were suspected. [1] [2] [3] [4] [5] [6] [7] After MRI, in addition to ZNS (serum level was 15.3 μg/mL), prednisolone (1 mg/kg, PO q24h for 4 days, then 0.5 mg/kg PO q24h for After the histologic diagnosis of LE, serum samples, which had been collected and stored when measuring ZNS levels, were analyzed for autoantibodies against leucine-rich glioma inactivated 1 (LGI1). [5] [6] [7] Immunological methods are summarized in the Supporting Information. A live cell staining using rat-cultured hippocampal neurons showed that the cat serum and human serum from a patient with LE (used as a positive control) contained antibodies to neuronal cell surface proteins ( Figure 3) . Additionally, the same procedure was performed in 3 healthy cats and 3 epileptic cats as negative controls.

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