Author: Zhang, XiZhen; Wang, XiaoDan; Zhao, DongHai; Meng, XiangYu; Zhao, XingHong; Yu, XiangHui; Kong, Wei
Title: Design and immunogenicity assessment of HIV-1 virus-like particles as a candidate vaccine Document date: 2011_12_16
ID: xxypq3wd_33
Snippet: VLPs are processed by antigen presenting cells (APCs) for MHC class I presentation to CD8 + cytotoxic T lymphocytes (CTL) [14] . To quantify the T-cell response, mice were injected with VLP (0.5, 2.5, 12.5, and 25 ïg) and DNA (100 ïg) using a 3-dose regimen. One week after the last injection, HIV-1-specific CD8 + T cells were measured in vitro by assessing the cell death of P815/BALB target cells, sensitized with an H-2 d -restricted CTL epit.....
Document: VLPs are processed by antigen presenting cells (APCs) for MHC class I presentation to CD8 + cytotoxic T lymphocytes (CTL) [14] . To quantify the T-cell response, mice were injected with VLP (0.5, 2.5, 12.5, and 25 ïg) and DNA (100 ïg) using a 3-dose regimen. One week after the last injection, HIV-1-specific CD8 + T cells were measured in vitro by assessing the cell death of P815/BALB target cells, sensitized with an H-2 d -restricted CTL epitope. The CTL response was low in the 0.5 ïg and DNA group, but increased in a dose-dependent manner. The highest CTL response was observed at 12.5 ïg (Figure 6 ), indicating that the CTL epitope is contained primarily in the NC domain of GAG (p7).
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