Author: DOKI, Tomoyoshi; TAKANO, Tomomi; HOHDATSU, Tsutomu
Title: Development of a mouse-feline chimeric antibody against feline tumor necrosis factor-alpha Document date: 2016_6_4
ID: y0x0quha_14
Snippet: Changes in neutralization activity of mouse mAb 2-4 and chimeric mAb 2-4 reacted with mouse mAb 2-4-or chimeric mAb 2-4-injected cat serum: Sera collected from the mAbtreated cats were diluted 10-fold with medium. The diluted sera were reacted for one hour with mouse mAb 2-4 or chimeric mAb 2-4 at the minimum concentration necessary for 80% or higher neutralization of 10 ng/ml recombinant fTNF-alpha. The reactant was then combined with recombinan.....
Document: Changes in neutralization activity of mouse mAb 2-4 and chimeric mAb 2-4 reacted with mouse mAb 2-4-or chimeric mAb 2-4-injected cat serum: Sera collected from the mAbtreated cats were diluted 10-fold with medium. The diluted sera were reacted for one hour with mouse mAb 2-4 or chimeric mAb 2-4 at the minimum concentration necessary for 80% or higher neutralization of 10 ng/ml recombinant fTNF-alpha. The reactant was then combined with recombinant fTNF-alpha (final concentration: 10 ng/ml). One hour later, the reactants were administered to WEHI-164 cells. The level of TNF-alpha-induced cytotoxicity was measured after 24 hr.
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