Author: DOKI, Tomoyoshi; TAKANO, Tomomi; HOHDATSU, Tsutomu
Title: Development of a mouse-feline chimeric antibody against feline tumor necrosis factor-alpha Document date: 2016_6_4
ID: y0x0quha_30
Snippet: In conclusion, we prepared mouse-feline chimeric mAb 2-4 by fusing the variable region of anti-fTNF-alpha mAb 2-4 to the feline antibody constant region and confirmed that it maintained fTNF-alpha neutralization activity. When the chimeric mAb 2-4 was administered to cats, the induction of feline anti-mouse antibody response was decreased compared to that after mouse mAb 2-4 administration. These results warrant further investigation on the dose .....
Document: In conclusion, we prepared mouse-feline chimeric mAb 2-4 by fusing the variable region of anti-fTNF-alpha mAb 2-4 to the feline antibody constant region and confirmed that it maintained fTNF-alpha neutralization activity. When the chimeric mAb 2-4 was administered to cats, the induction of feline anti-mouse antibody response was decreased compared to that after mouse mAb 2-4 administration. These results warrant further investigation on the dose and dosing frequency of chimeric mAb 2-4 appropriate for effective treatment of cats with FIP.
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