Clinical Characteristics of Hospitalized Patients with SARS-CoV-2 and Hepatitis B virus Co-infection

Xiaoping Chen; Qunqun Jiang; Zhiyong Ma; Jiaxin Ling; Wenjia Hu; Qian Cao; Pingzheng Mo; Rongrong Yang; Shicheng Gao; Xien Gui; Yong Xiong; Jinlin Li; Yongxi Zhang

is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.03.23.20040733 doi: medRxiv preprint from more severe situation during the disease progress when were encountered with SARS-CoV-2 infection. In our enrolled cases, two patients with SARS-CoV and HBV coinfection died on admission. One patient died from severe liver disease, haptic sclerosis. And the other died from intestinal hemorrhage, which seems to be associated the impairment of gastrointestinal tract. More coinfection cases analysis are required to further understand whether SARS-CoV-2 infection aggerates the progress of pre-existing disease and thereby cause death. There are different phases for HBV chronic infection including immunotolerant, viral suppression under longterm treatment with nucleotide analogues. In our current study, we collected the data of HBV on 15 coinfection patients at one time point, which were mainly used to identify HBV infection. More coinfection cases analysis is required to provide further evidences for evaluating the effects of SARS-CoV-2 infection on active HBV replication and live impairment at different time points for the HBV patients in different phases.