Author: Maroun, Justin; Muñoz-Alía, Miguel; Ammayappan, Arun; Schulze, Autumn; Peng, Kah-Whye; Russell, Stephen
Title: Designing and building oncolytic viruses Document date: 2017_3_31
ID: qr1gsmqw_60
Snippet: Immediately following OV infection, tumor cells release type I interferons, driving innate and inflammatory immune responses [161] . Subsequently, they undergo necrosis releasing tumor antigens into the interstitial space where they are phagocytosed by inflammatory effector cells and transported to regional lymph nodes for cross-presentation to helper and effector T cells which proliferate, re-enter the bloodstream, traffic back to the tumor, ext.....
Document: Immediately following OV infection, tumor cells release type I interferons, driving innate and inflammatory immune responses [161] . Subsequently, they undergo necrosis releasing tumor antigens into the interstitial space where they are phagocytosed by inflammatory effector cells and transported to regional lymph nodes for cross-presentation to helper and effector T cells which proliferate, re-enter the bloodstream, traffic back to the tumor, extravasate from tumor neovessels, engage the neoantigenic MHC-peptide complexes on uninfected tumor cells and kill them [162] [163] [164] .
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