Selected article for: "ex vivo infection and major target"
Author: Chen, Yongxiong; Chan, Vera Sau-Fong; Zheng, Bojian; Chan, Kelvin Yuen-Kwong; Xu, Xiaoning; To, Leo Yuk-Fai; Huang, Fang-Ping; Khoo, Ui-Soon; Lin, Chen-Lung Steve
Title: A novel subset of putative stem/progenitor CD34(+)Oct-4(+) cells is the major target for SARS coronavirus in human lung
  • Document date: 2007_10_29
    • ID: u4qhk802_20
    Snippet: Whether or not these CD34 Ï© cells are also the major target for SARS-CoV in the early phase of infection remains to be investigated. Our ex vivo infection model in part can be a complement to actual early infection. However, in vivo confi rmation of the identity of virus-targeted cells in the early phase is diffi cult because of unavailability of samples from patients who died within 3 d after illness onset or even before the onset. Extrapolatio.....
    Document: Whether or not these CD34 Ï© cells are also the major target for SARS-CoV in the early phase of infection remains to be investigated. Our ex vivo infection model in part can be a complement to actual early infection. However, in vivo confi rmation of the identity of virus-targeted cells in the early phase is diffi cult because of unavailability of samples from patients who died within 3 d after illness onset or even before the onset. Extrapolation of animal studies to humans for early infection also requires much caution because iatrogenic inoculation with large-volume viral droplets into animals is different from infection in a more natural aerosol form in human settings ( 30 ) . Moreover, the value and reproducibility of the nonhuman primate model for SARS infection are also highly disputable ( 31, 32 ) .

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