Author: André, Nicole M; Cossic, Brieuc; Davies, Emma; Miller, Andrew D; Whittaker, Gary R
Title: Distinct mutation in the feline coronavirus spike protein cleavage activation site in a cat with feline infectious peritonitis-associated meningoencephalomyelitis Document date: 2019_6_26
ID: tac1unnp_14
Snippet: This case report describes a young cat with neurologic FIP in which detailed clinical and molecular characterization of the associated FCoV infection was performed. While the etiology of FIP remains complex and likely involves multiple mutations in the viral genome, our results indicate that a specific mutation of the viral spike protein can be associated with infection of the CNS, which may explain the tropism to the CNS as opposed to other orga.....
Document: This case report describes a young cat with neurologic FIP in which detailed clinical and molecular characterization of the associated FCoV infection was performed. While the etiology of FIP remains complex and likely involves multiple mutations in the viral genome, our results indicate that a specific mutation of the viral spike protein can be associated with infection of the CNS, which may explain the tropism to the CNS as opposed to other organ systems.
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