Selected article for: "late phase and liver injury"
Author: Fang, H; Liu, A; Dahmen, U; Dirsch, O
Title: Dual role of chloroquine in liver ischemia reperfusion injury: reduction of liver damage in early phase, but aggravation in late phase
  • Document date: 2013_6_27
    • ID: qmut89kb_12
    Snippet: It has been reported that chloroquine-induced apoptosis both in vitro and in vivo via the inhibition of autophagic protein degradation. [17] [18] [19] [20] Prompted by these findings, we focused our studies on the expression of the apoptotic protein caspase-3 and caspase-7. As shown in Figure 6 , caspase-3 cleavage was increased in response to liver I/R. In contrast, chloroquine treatment increased liver I/R-induced caspase-3 cleavage. Furthermor.....
    Document: It has been reported that chloroquine-induced apoptosis both in vitro and in vivo via the inhibition of autophagic protein degradation. [17] [18] [19] [20] Prompted by these findings, we focused our studies on the expression of the apoptotic protein caspase-3 and caspase-7. As shown in Figure 6 , caspase-3 cleavage was increased in response to liver I/R. In contrast, chloroquine treatment increased liver I/R-induced caspase-3 cleavage. Furthermore, as with caspase-3, chloroquinetreated rats demonstrated significantly higher hepatic cleaved caspase-7 levels when compared with vehicleinjected rats. These data indicate that chloroquine treatment could increase I/R-induced apoptosis. Induction of apoptosis in the late phase of reperfusion was associated with an increased hepatic injury as indicated by the elevated liver enzyme and the severe histopathologic changes.

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