Selected article for: "chloroquine administration and hepatic apoptosis"
Author: Fang, H; Liu, A; Dahmen, U; Dirsch, O
Title: Dual role of chloroquine in liver ischemia reperfusion injury: reduction of liver damage in early phase, but aggravation in late phase
  • Document date: 2013_6_27
    • ID: qmut89kb_23
    Snippet: Experimental design. The experiments were designed to investigate the effects of chloroquine administration on rat hepatic I/R injury. Rats were treated with chloroquine (60 mg/kg, i.p.) 1 h before warm ischemia, and they were continuously subjected to a daily chloroquine injection for up to 2 days. Rats were killed 0.5, 6, 24 and 48 h after reperfusion. Liver injury, inflammatory cytokines, hepatic HMGB1 expression and release, MAP kinase activa.....
    Document: Experimental design. The experiments were designed to investigate the effects of chloroquine administration on rat hepatic I/R injury. Rats were treated with chloroquine (60 mg/kg, i.p.) 1 h before warm ischemia, and they were continuously subjected to a daily chloroquine injection for up to 2 days. Rats were killed 0.5, 6, 24 and 48 h after reperfusion. Liver injury, inflammatory cytokines, hepatic HMGB1 expression and release, MAP kinase activation, autophagy and apoptosis were analyzed.

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