Author: DOKI, Tomoyoshi; TAKANO, Tomomi; HOHDATSU, Tsutomu
Title: Development of a mouse-feline chimeric antibody against feline tumor necrosis factor-alpha Document date: 2016_6_4
ID: y0x0quha_20
Snippet: Repeated-dose test in cats: Purified mouse mAb 2-4 and chimeric mAb 2-4 were repeatedly administered to SPF cats at 2-or 4-week intervals, and the blood pressure and pulse were measured before and after administration ( Table 2) . Body temperature tended to decrease after administration of PBS, mouse mAb 2-4 and chimeric mAb 2-4 throughout the period with 5 administrations, but no significant difference was observed among the 3 groups. Neither we.....
Document: Repeated-dose test in cats: Purified mouse mAb 2-4 and chimeric mAb 2-4 were repeatedly administered to SPF cats at 2-or 4-week intervals, and the blood pressure and pulse were measured before and after administration ( Table 2) . Body temperature tended to decrease after administration of PBS, mouse mAb 2-4 and chimeric mAb 2-4 throughout the period with 5 administrations, but no significant difference was observed among the 3 groups. Neither were there any differences in blood pressure or pulse between the groups or due to dosing frequency.
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