Author: Spence, Jennifer S.; Krause, Tyler B.; Mittler, Eva; Jangra, Rohit K.; Chandran, Kartik
Title: Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway Document date: 2016_2_9
ID: tnaizwxo_25
Snippet: While this initial study focused primarily on the GP triggering and lipid mixing steps of EBOV entry, further work is needed to elucidate outstanding issues, such as the precise mechanism that explains why post-NPC1-binding cathepsin activity is required for infection but not lipid mixing. Future live-cell studies will examine the dynamics of fusion pore expansion and viral genome release and provide a more comprehensive understanding of the EBOV.....
Document: While this initial study focused primarily on the GP triggering and lipid mixing steps of EBOV entry, further work is needed to elucidate outstanding issues, such as the precise mechanism that explains why post-NPC1-binding cathepsin activity is required for infection but not lipid mixing. Future live-cell studies will examine the dynamics of fusion pore expansion and viral genome release and provide a more comprehensive understanding of the EBOV entry process.
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