Author: Okazaki, Shunichiro; Nagoya, Satoshi; Matsumoto, Hiroshi; Mizuo, Keisuke; Sasaki, Mikito; Watanabe, Satoshi; Yamashita, Toshihiko; Inoue, Hiromasa
Title: Development of non-traumatic osteonecrosis of the femoral head requires toll-like receptor 7 and 9 stimulations and is boosted by repression on nuclear factor kappa B in rats Document date: 2014_11_10
ID: r5hqj5ib_13
Snippet: To evaluate the incidence of ONFH, rats in the Saline þ MPSL (n ¼ 12) used as a control, Imiquimod þ MPSL (n ¼ 12) and CpG-C þ MPSL (n ¼ 12) groups were killed 14 days after the MPSL injection. ONFH was observed in 6 of 12 rats in the Imiquimod þ MPSL group and 4 of 12 rats in the CpG-C þ MPSL group. By contrast, no ONFH was observed in the Saline þ MPSL group (0 of 12) ( Table 2 ). The incidence of ONFH in the Imiquimod þ MPSL group wa.....
Document: To evaluate the incidence of ONFH, rats in the Saline þ MPSL (n ¼ 12) used as a control, Imiquimod þ MPSL (n ¼ 12) and CpG-C þ MPSL (n ¼ 12) groups were killed 14 days after the MPSL injection. ONFH was observed in 6 of 12 rats in the Imiquimod þ MPSL group and 4 of 12 rats in the CpG-C þ MPSL group. By contrast, no ONFH was observed in the Saline þ MPSL group (0 of 12) ( Table 2 ). The incidence of ONFH in the Imiquimod þ MPSL group was significantly higher from that in the Saline þ MPSL group (Po0.01; Fisher's exact test). Figure 1 shows the
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