Author: Zhou, Jie; Li, Cun; Sachs, Norman; Chiu, Man Chun; Wong, Bosco Ho-Yin; Chu, Hin; Poon, Vincent Kwok-Man; Wang, Dong; Zhao, Xiaoyu; Wen, Lei; Song, Wenjun; Yuan, Shuofeng; Wong, Kenneth Kak-Yuen; Chan, Jasper Fuk-Woo; To, Kelvin Kai-Wang; Chen, Honglin; Clevers, Hans; Yuen, Kwok-Yung
Title: Differentiated human airway organoids to assess infectivity of emerging influenza virus Document date: 2018_6_26
ID: z637eh2z_9
Snippet: PD AOs Can Identify Human-Infective Virus. One of the most important and challenging issues for influenza research is to predict which animal or emerging influenza virus can infect humans. As mentioned above, the novel reassortant avian H7N9 viruses have caused continuing poultry-to-human transmission since 2013. In fact, other subtypes of avian IAVs, including H7N2, H9N2, and H9N9, have been cocirculating with the H7N9 viruses in domestic poultr.....
Document: PD AOs Can Identify Human-Infective Virus. One of the most important and challenging issues for influenza research is to predict which animal or emerging influenza virus can infect humans. As mentioned above, the novel reassortant avian H7N9 viruses have caused continuing poultry-to-human transmission since 2013. In fact, other subtypes of avian IAVs, including H7N2, H9N2, and H9N9, have been cocirculating with the H7N9 viruses in domestic poultry. These viruses are highly similar in internal genes but differ in neuraminidase (NA) or HA and NA (19) . However, very few human infections by H7N2, H9N2, and H9N9 virus have been reported in the same territory and time frame, although people were exposed equivalently to these viruses and the H7N9 viruses (20) ; these findings suggest that these viruses are less infective to humans than the H7N9 viruses.
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