Author: Spence, Jennifer S.; Krause, Tyler B.; Mittler, Eva; Jangra, Rohit K.; Chandran, Kartik
Title: Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway Document date: 2016_2_9
ID: tnaizwxo_18
Snippet: We found, unsurprisingly, that the majority of cell-associated particles did not advance to lipid mixing (Fig. 2D) . The low probability of lipid mixing suggests that the results of previously published experiments utilizing bulk endocytosis may be misleading, with an inadvertent focus on nontriggered virions. This presents a particular obstacle in determining factors involved in EBOV GP fusion triggering or the compartment(s) in which triggering.....
Document: We found, unsurprisingly, that the majority of cell-associated particles did not advance to lipid mixing (Fig. 2D) . The low probability of lipid mixing suggests that the results of previously published experiments utilizing bulk endocytosis may be misleading, with an inadvertent focus on nontriggered virions. This presents a particular obstacle in determining factors involved in EBOV GP fusion triggering or the compartment(s) in which triggering occurs.
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