Author: Spence, Jennifer S.; Krause, Tyler B.; Mittler, Eva; Jangra, Rohit K.; Chandran, Kartik
Title: Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway Document date: 2016_2_9
ID: tnaizwxo_9
Snippet: The need for host cysteine cathepsin cleavage of EBOV GP in infection is well established (19, 35) . Pan-cysteine cathepsin inhibitors, such as E-64d, prevent entry by filoviruses, which differ in their preference for cleavage by cathepsin B or L (19, 41) . We found that E-64d treatment reduced EBOV GP⌬Muc-mediated lipid mixing by more than 90%, while lipid mixing by VSV G-bearing particles was not similarly affected (Fig. 3B) , demonstrating t.....
Document: The need for host cysteine cathepsin cleavage of EBOV GP in infection is well established (19, 35) . Pan-cysteine cathepsin inhibitors, such as E-64d, prevent entry by filoviruses, which differ in their preference for cleavage by cathepsin B or L (19, 41) . We found that E-64d treatment reduced EBOV GP⌬Muc-mediated lipid mixing by more than 90%, while lipid mixing by VSV G-bearing particles was not similarly affected (Fig. 3B) , demonstrating that a lack of cysteine cathepsin activity hinders downstream events in lipid mixing for EBOV GP.
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